VERSIONS OF THE TAIL PART OF REDOX-ACTIVE MEDICINES FOR THE TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY METABOLISM

摘要

Methods for treating or suppressing mitochondrial diseases such as Frederick's ataxia (FRDA), Leber's hereditary optic nerve neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactic acidosis, stroke (MELAS) or Kearns-Sayre syndrome (KSS), and also useful compounds are disclosed. in the methods of the invention. Also disclosed are biomarkers of energy metabolism useful for assessing the metabolic state of a subject and the effectiveness of treatment.