NITROOXYDERIVATIVES OF CARVEDILOL AND OTHER BETA BLOCKERS AS ANTIHYPERTENSIVE DRUGS

摘要

The present invention relates to beta-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y-ONO2)s, wherein s is an integer equal to 1 or 2; A is selected from the following beta-adrenergic blockers residues of formula (II), wherein R1 is selected from the group consisting of: formula (IIa), formula (IIb), formula (IIc) or other residues defined in claim 1; R2 is selected from the group consisting of: -CH(CH3)2, -C(CH3)3 or formula (IIIa), formula (IIIb), Z is H or is a group capable of binding Y as defined in claim 1, Z1 is H or a -C(O)- capable of binding Y; the other substituents are defined in claim 1; and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.