A POLYPEPTIDE CONTAINING THE GAFA DOMAIN AND THE GAFB DOMAIN OF A HUMAN PHOSPHODIESTERASE 11(PDE11) AND METHODS FOR IDENTIFYING PDE11 MODULATORS UTILIZING THE SAME

摘要

The invention relates to a novel GAFA domain-containing polypeptide, to the GAFA domain of a human phosphodiesterase 11 (PDE11) and to the adenylate cyclase catalytic domain. The use of said polypeptide in a method for identifying PDE11-modulators is also disclosed.