RETROVIRAL VECTOR PARTICLE HAVING A RETROVIRAL ENVELOPE PROTEIN MODIFIED TO BIND COLLAGEN, METHOD OF GENERATING IT AND USE THEREOF IN PREPARING A MEDICAMENT FOR EXPRESSING A THERAPEUTIC AGENT IN AN ANIMAL

摘要

A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.