A PROCESS FOR TH SYNTHESIS OF 1-(4-ARYLPIPERAZIN-1-YL)-ω-(2,5-DIOXOPYRROLIDIN-1-YL)ALKANES AS α1-ADRENORECEPTOR BLOCKERS USEFUL FOR HYPERTENSION AND BENIGN PROSTATIC HYPERPLASIA (BPH)

摘要

A process for the Preparation of I- (4-ARYLPIPKRAZIN - I - YL) -  - (2, 6-dioxopiperidin-1-yl) alkanes of Formula III, as selected a I - adrenoceptor blockers useful for the treatment of benign prostatic hyperplasia (BPH) and hypertension, as shown in the accompanied drawings, wherein R represents group like chlorophenyl fluorophenyl, methylphenyl, methoxyphenyl, pyridyl, pyrimidyl, di-methylphenyl and trifluoromethylphenyl and n = 2-4, which comprises condensing 2,6-dioxoperidine of formla I With l-(4-arylpiperazin-l-yl) - -chloro-alkanes of the formula II as shown in the accompanied drwings, wherein R and n have the same meanings as defined above, in the presence of a base and a phase transfer catalyst tetrabuyl ammonium bromide and potassium iodide in an organic solvent at a temperature ranging upto I50°C.