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AN IMPROVED PROCESS FOR THE PREPARATION OF LEVOFLOXACIN HAVING SINGLE INDIVIDUAL IMPURITY NOT MORE THAN 0.1 IN THE FORM OF LEVOFLOXACIN HEMIHYDRATES
AN IMPROVED PROCESS FOR THE PREPARATION OF LEVOFLOXACIN HAVING SINGLE INDIVIDUAL IMPURITY NOT MORE THAN 0.1 IN THE FORM OF LEVOFLOXACIN HEMIHYDRATES
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机译:左氧氟沙星半水合物形式的单一个体杂质含量不超过0.1%的左氧氟沙星的制备工艺得到改进
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摘要
: This invention relates to an improved process for the preparation of Levofloxacin having single individual impurity not more than 0.1 % and free from particulate matter & from the other enantiomer (R-form) in the form of Levofloxacin Hemihydrate. More specially, the invention provides an improved process for the preparation of high purity form of Levofloxacin hemihydrate from Levofloxacin Q acid and Levofloxacin technical. The Levofloxacin in the form of LevohuAacin Hemihydrate prepared has a single individual impurity less than 0.1% free from particulate matter and other enantiomer (R-form). Levofloxacin form prepared by the process of the present invention is useful as an antibacterial. The invention also relates to an improved process for the preparation of the above pure fonD of Levofloxacin starting from 2,3,4,5 - tetrafluoro benzoic acid through the intermediates Levofloxacin Q acid and Levofloxacin technical.
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