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A NOVEL HOMOLOGY BUILT MODEL OF THE GLYCOGEN SYNTHASE KINASE 3 ALPHA AND ITS USES THEREOF
A NOVEL HOMOLOGY BUILT MODEL OF THE GLYCOGEN SYNTHASE KINASE 3 ALPHA AND ITS USES THEREOF
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机译:糖原合酶激酶3α的新同源性构建模型及其应用
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摘要
A The present invention provides a novel homology three-dimensional structure of Glycogen Synthase Kinase 3- Alpha (GSK3- Alpha) or a variant thereof for screening, designing and/or synthesizing a modulator that modulates the activity of GSK3- Alpha and method of generating said three dimensional structure thereof. The three-dimensional structure of GSK3-Alpha is defined by at least a portion of structural co-ordinates of Table 1. Further, the present invention provides a computer assisted system for generating said three-dimensional structure of GSK3-Alpha or a variant thereof. Further, the present invention relates to a method of screening, designing and/or synthesizing a modulator for modulating the activity ofGSK3-alpha or a variant thereof.
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