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A RECOMBINANT MOUSE-HUMAN CHIMERIC FAB AGAINST HEPATITIS B SURFACE ANTIGEN
A RECOMBINANT MOUSE-HUMAN CHIMERIC FAB AGAINST HEPATITIS B SURFACE ANTIGEN
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机译:抗肝炎乙型肝炎表面抗原的重组鼠-人嵌合抗体
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摘要
This invention relates to a recombinant chimeric Fab antibody comprising a recombinant Fd and a recombinant chimeric light chain which binds to hepatitis B surface antigen with high affinity, generated by fusing variable region genes (VH and VL) of an anti-HBsAg mouse antibody 5S and constant region genes of human, CH1 region of human IgGI and the CL region of human kappa chain, wherein mouse VL and human CL are linked by overlap PCR to generate chimeric light chain and mouse VH and CH1 are linked by overlap PCR to generate chimeric Fd.
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