A NOVEL AND IMPROVED PROCESS FOR THE PREPARATION OF IRBESARTAN, AN ANGIOTENSIN-II RECEPTOR ANTAGONIST FOR THE TREATMENT OF HYPERTENSION

摘要

2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1, 3-diaza-spiro[4,4]non-1-en-4-one is prepared by reacting 1-(2’-cyanobiphenyl-4-yl)methyl)-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one with sodium azide and zinc halide, in organic solvent.