SODIUM HYALURONATE POLYMER OF TAILORED MOLECULAR WEIGHT FOR TREATMENT OF OSTEOARTHRITIS WITH MINIMIZED SIDE EFFECTS

摘要

The present invention relates to Sodium Hyaluronate Polymer of tailored molecular weights. In one embodiment, tailored molecular weight of hydrolysed Sodium hyaluronate polymer range from about 0.6-1.45 million Dalton. To obtained tailored molecular weights of Sodium hyaluronate firstly Bulk Sodium hyaluronate, is extracted from the tissues of rooster combs. Then extract bulk Sodium hyaluronate, is steam hydrolyzed at about 100-130oC, pressure of about 0.3-1.8 atmosphere for about 10-90 minutes and isolating the product. Tailoring of molecular weight of Sodium hyaluronate is done precisely under the solution state then under solid state conditions.