INT6 PROTEIN INVOLVED IN HYPOXIC STRESS RESPONSE AND USE THEREOF

摘要

The present inventors successfully identified an HIF2a binding factor, Int6, which has binding activity to the HIF2α, as a factor involved in hypoxic stress response that promotes angiogenesis. Furthermore, the present inventors discovered that Int6 suppresses HIF2α-mediated transcription of hypoxic stress-responsive genes by interacting with HIF2α. Substances that inhibit Int6 expression or its function promote angiogenesis by enhancing the activity of HIF2a to promote transcription of hypoxic stress-responsive genes, and are expected to have therapeutic effects for various vascular diseases including myocardial infarction.