LIPOSOMAL DRUG DELIVERY SYSTEM FOR AMPHOTERICIN-B DRUG

摘要

The delivery by liposome technology gives us the advantage to deliver toxic drugs to the without causing damage to the normal cells. Also, many drugs with low aqueous solubility and/or combination of both water-soluble and lipid soluble drugs can be formulated in the liposomes, increasing the bioavailability of the drug, reducing dosage and also reducing systemic toxicity. Amphotercin B is a amphiphilic drug and it is intercalated into a liposomal membrane. Amphotericin B is a antifungal used in the treatment of confirmed infections caused by various fungal species or visceral leishmaniasis, a parasitic infection. Additionally, Amp-B is used to treat patients who are refractory to or intolerant of conventional amphotericin B therapy. It is available both in the normal and liposomal injection form.