AN OPGL ANALOGUE FOR DOWN-REGULATING OSTEOPROTEGERIN LIGAND ACTIVITY

摘要

The present invention provides a novel method for down-regulating rendering the biological activity of osteoprotegering ligand (OPGL TRANCE) thereby rendering possible the treatment/amelioration of diseases characterized by excessive loss of bone mass, e.g. osteoporosis. Down-regulation is effected by including an immune response against OPGL in an individual in need thereof. Immune responses can be raise by classical immunization with immunogenic variants of OPGL or by nucleic acid immunization where the nucleic acide encode the OPGL variant. The invention also pertains to compositions, polypeptides and nucleic acide useful in the invention, as well as to vectors and transformed host cells useful in the preparation thereof.