A PROCESS FOR PREPARING TOPICAL COMPOSITION FOR REDUCING HAIR GROWTH THROUGH FOLLICULAR DELIVERY OF AN ORNITHINE DECARBOXYLASE INHIBITOR

摘要

Polyethylene glycol ethers of alkyl alcohols having the general formula CH3(,CH2)xCH2(OCH2CH;)nOH wherein x is 8 to 20 (of which cetcareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyI do-decylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2(difluoromelhyl)-2,5-diamino pentanoic acid and its phannaceutically acceptable salts, hydrates, optical cnantiomers and raccmic mixture are preferred.