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METHODS TO IDENTIFY THERAPEUTIC AGENTS USEFUL FOR TREATING AND PREVENTING ATHEROSCLEROSIS BY COUNTERACTING THE EFFECT OF CHOLESTEROL OZONATION PRODUCTS.
METHODS TO IDENTIFY THERAPEUTIC AGENTS USEFUL FOR TREATING AND PREVENTING ATHEROSCLEROSIS BY COUNTERACTING THE EFFECT OF CHOLESTEROL OZONATION PRODUCTS.
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机译:通过抵消胆固醇氧化产物的作用来鉴定治疗和预防动脉粥样硬化有用的治疗剂的方法。
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摘要
As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present application is directed to methods of using such cholesterol ozonoation products to identify agents that can be used to treat atherosclerosis and other inflammatory artery diseases.
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