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METHOD FOR THE PRODUCTION OF ANTIBODIES IN IMMUNODEFICIENT ANIMAL INJECTED WITH HUMAN FETAL LIVER STEM CELLS.
METHOD FOR THE PRODUCTION OF ANTIBODIES IN IMMUNODEFICIENT ANIMAL INJECTED WITH HUMAN FETAL LIVER STEM CELLS.
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机译:在人胎肝干细胞注射的免疫缺陷动物中生产抗体的方法。
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摘要
The current invention is related to a method for the production of a human monoclonal antibody from an immundeficient non-human animal, said method comprising contacting a newborn immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non- human animal (reconstituted animal), subsequently contacting said reconstituted animal with an antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
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