PROSTAGLANDIN COMPOSITIONS AND METHODS OF TREATMENT FOR MALE ERECTILE DYSFUNCTION.

摘要

The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erectioninducing amount of a prostaglandin E1 composition of a semisolid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl2(N,Ndisubstituted amino)alkanoate ester, an (N,Ndisubstituted amino)alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.