Method for the treatment of acne using an oral minocycline antibiotic

摘要

Disclosed is the use of a continuous slow release oral dosage form to treat acne vulgaris wherein the dosage form comprises: an amount of an oral minocycline antibiotic that provides the person, upon administration of said oral dosage form once daily without a loading dose, with 0.7 mg/kg/day to 1.3 mg/kg/day of said oral minocycline antibiotic; and a delivery vehicle, wherein said delivery vehicle releases said oral minocycline antibiotic at a release rate of: (a) about 25% to about 52% within about I hour, about 53% to about 89% within about 2 hours, and at least about 90% within about 4 hours; or (b) about 30% to about 52% within about 1 hour, about 53% to about 84% within about 2 hours, and at least about 85% within about 4 hours. Also disclosed are oral dosage forms for use in the above method.