method for predicting the sensitivity of a cell or tissue sample, method for inducing apoptosis in a cell or tissue sample, method of treating a dysfunction, and using apo2l / trail

摘要

METHOD FOR PREVENTING THE SENSITIVITY OF A CELL OR TISSUE SAMPLE, METHOD FOR INDUCING APOPTOSIS IN A CELL OR TISSUE SAMPLE, METHOD OF TREATING DYSFUNCTION AND USE OF APO2L / TRAIL The present invention relates to methods and tests that examine expression of one or more biomarkers in a mammalian cell or tissue sample. According to the published methods and tests, the detection of the expression of GalNac-T-related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the cell or tissue sample will be sensitive to apoptosis such as Apo2LITRAIL and anti-DR5 agonist antibodies. Kits and manufacturing items are also provided.