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Antibodies, antibody fragments and antibody derivatives that bind specifically insulin-like growth factor-I receptor and inhibit the cellular activity of the receptor by antagonizing the receptor
Antibodies, antibody fragments and antibody derivatives that bind specifically insulin-like growth factor-I receptor and inhibit the cellular activity of the receptor by antagonizing the receptor
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机译:特异性结合胰岛素样生长因子-I受体并通过拮抗受体抑制细胞活性的抗体,抗体片段和抗体衍生物
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摘要
Disclosed herein are antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit, insulin-like growth factor-I receptor, antagonize the effects of IGF-I, IGF-II and serum on the growth and survival of tumor cells, and which are substantially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, prostate cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor.
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