Use of the quinazoline derivative ZD6474 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability

摘要

Disclosed is a pharmaceutical composition which comprises ZD6474 or a pharmaceutically acceptable salt thereof, and gemcitabine, in association with a pharmaceutically acceptable excipient or carrier. Also disclosed is the use of the above composition in the manufacture of a medicament, optionally combined with ionising radiation treatment, for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal, or for use in the production of an anti-cancer effect in a warm-blooded animal.