Use of murine genomic regions identified to be involved in tumor development for the development of anit-cancer drugs and diagnosis of cancer

摘要

Disclosed are murine genomic regions identified by retroviral insertional tagging of mice as being involved in tumor development. In particular, the genomic regions involved in leukemia development, as well as their human homologues, and the use of these genomic regions for the identification and development of anti-cancer drugs. These drugs include small molecule inhibitors, antibodies, ribozymes, antisense molecules and RNA interference (RNAi) molecules, that are effective in reducing or eliminating the tumorigenic effects of genetic transformations in these genomic regions and/or eliminating the tumorigenic effects of expression products. Also disclosed are; anti-cancer drugs and their use for the treatment of cancer, pharmaceutical compositions their use compositions for the treatment of cancer.