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Immunotherapeutic compositions and methods for the treatment of moderately to well-differentiated prostrate cancers
Immunotherapeutic compositions and methods for the treatment of moderately to well-differentiated prostrate cancers
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机译:免疫治疗组合物和方法,用于治疗中度至高度分化的前列腺癌
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摘要
Disclosed is an immunotherapeutic composition comprising activated, isolated autologous antigen presenting cells (APCs) of a patient diagnosed with prostrate cancer having a moderate to well differentiated cancer grade and a Gleason score of 7 or less, wherein the APCs are stimulated by exposure ex vivo to a fusion protein composed of human granulocyte macrophage colony stimulating factor (huGM-CSF) and a polypeptide having at least 80% amino acid sequence identity to the sequence identified by SEQ ID NO:1 (huPAP).
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机译:公开了一种免疫治疗组合物,其包含被诊断患有中度至高度分化的癌症等级且格里森评分为7或更低的前列腺癌患者的活化的,分离的自体抗原呈递细胞(APC),其中所述APC通过离体暴露于由人粒细胞巨噬细胞集落刺激因子(huGM-CSF)和与SEQ ID NO:1(huPAP)鉴定的序列具有至少80%氨基酸序列同一性的多肽组成的融合蛋白。
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