Humanized antibody specific for TSLP (thymic stromal lymphopoietin) and Pharmaceutical compositions

摘要

Refers to a Humanized Antibody to isolated or a functional fragment comprising an Antigen binding region that is specific to TSLP (thymic stromal lifopoyetina human) with a KD of 1x10 - 9 m or less.Said Antibody comprises: (a) a region (SEQ ID no: CDR1 selected 38, a selected region L - CDR2 of SEQ ID no: 47, a L - Selected CDr3 region of SEQ ID no: 60; (b) a selected region (SEQ ID no: CDR1 Region 3, H - CDR2 selected seq id: SEQ ID: 15, 17, 18, SEQ ID: SEQ ID : 19SEQ ID: 20 and CDR3 Region H - Selected SEQ ID: 28 and Conservative variants of the same. Also referred to a Pharmaceutical composition with pharmaceutically acceptable excipients. This Antibody is useful in the treatment of diseases such as Asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma