Heterocyclic compounds as inhibitors of the kinase 2 Protein Activated by mitogen activated protein kinase

摘要

Relates to Heterocyclic compounds of formula (i) wherein R1 is Halogen, Hydroxy, mercapto, CN, among others; X is o, s or Noh; R2 is (A - c) - (q) where Q and H or alkyl (C1 - C6); a is H or alkyl (C1 - C6); and is oxilo amino, amino, hydroxyl, alkoxyl (C1 - C6), among others; R3 is - Oh,- or where nhr4 or4 - R4 is H or alkyl (C1 - C6); and R2 and R3 are connected together to form a Ring of five to Seven members; R7 is H or alkyl (C1 - C6) optionally substituted with amino, hydroxyl, carboxyl or Halogen.Hydrochloride acid compounds are preferred: 2 - amino - methyl - 4 - ((e) - styryl) - 1H pyrrolo [2,3] - - - - - isoquinolin F 3 carboxylic acid, 2 - ((e) - styryl) - 3,8,10 9,10 dihydro - 8h - - - - - triaza pentalen [2.1 - naftalen] - 7 - ona, hydrochloride acid, 2 - methyl - 4 - amino - chlorine - 1H pyrrolo [2,3] - - - - - isoquinolin F 3 carboxylic acid, between Others. It also relates to a Pharmaceutical Composition and a preparation method.These compounds are inhibitors of the kinase 2 Protein Activated by mitogen activated protein kinase (MAPKAPK2) being useful in the treatment of rheumatoid arthritis, Ankylosing Spondylitis, hemolytic anemia, gastritis, systemic lupus erythematosus