Polymorphic forms of 8 - (2,6 - difluorofenil) - 4 - (4 - fluoro - 2-methylphenyl) - 2 - {2-hydroxy-1 - (hydroxymethyl) ethyl amino} pirido 2,3-d pyrimidine 7 (8h) - ona tosylate

摘要

Refers to polymorphic forms of 8 - (2,6 - difluorofenil) - 4 - (4 - fluoro - 2-methylphenyl) - 2 - {[2-hydroxy-1 - (hydroxymethyl) ethyl] amino} pirido [2,3-d] pyrimidine 7 (8h) - ona tosylate, where 1 is characterised by presenting a pattern of x-ray diffraction Angles 2 expressed in Shows peaks at 7.5, 8, 9 9, 13.0, 16.3, 19.8 21.1, 21.8, + / - 0.1, among others; an infrared Spectrum with Peaks of 3442, 3219, 3072, 2935, 1697, 1654, 1619, 1558, 1501, 1479, 1247, 1150, 1119, 1107, 1076, 1062, 1030, 1011, 1005, 983, 947, 913, 876, 838, 820 798 and 709 cm - 1, among others; a home of fusion to 230 degrees Celsius; the same way are characterized the Polymorphic Forms 2, 3 and 4.It also relates to a preparation method and a Pharmaceutical composition; this Compound modulates the activity of p38 kinase, being useful in the treatment of acute inflammatory processes of COPD, Asthma, cystic fibrosis,