It refers to the preparation process of 3 (R) bromine (2-hydroxi-2, 2-ditien-2-ilacetoxy) - 1 - (3-phenylpropyl) - 1-azonibcyclo [2.2.2] octano, including the reaction of 2-hydroxi-2, 2-ditien-2-ilacetico and 3-phenyl bromuro's acido azabicycleo [2.2.2], In the range of 1.0 to 3.0, the ratio of brominated equivalent to esters varies; in this range, the reaction takes place in a solvent or mixture of solvents selected from cetaceans and cyclohexanes, while tetrahydrofuran is preferred;At the boiling point of 50-210 ℃, it is better not to exceed 6 hours in a period of not more than 24 hours. This procedure allows for reduction of reaction time, number of solvents, use of lease reactions, while improving performance and maintaining levels of inert impurities. This allows us to reduce the reaction time, the number of solvents, the rental reaction used, while improving performance and maintaining impurity levels
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