Pharmaceutical Controlled Release System, particularly oral administration of active substances with solubilities of pH, Preparation and Application.

摘要

Pharmaceutical Controlled Release System (independent of pH) for oral administration, in particular, of active substances with pH dependent solubility, comprising core Material containing or consisting of one or more pharmaceutically acceptable pH Modifiers And the following Layers: a) optionally a Insulator(c) a First comprising one or more pharmaceutically acceptable Polymer insoluble in water; (d) a Second comprising at least one active substance with a pH dependent solubility; (e) a Third comprising one or more pharmaceutically acceptable Polymer containing gr UPOS Anionic or nonionic; (f) and optionally a Fourth,Preferably in the form of External Coating.