USE OF ALPHA, BETA UNSATURATED ARYLSULPHONES FOR THE PROTECTION OF CELLS AND TISSUE FROM TOXICITY OF IONIC RADIATION

摘要

Pre-treatment with alpha,beta unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective alpha,beta unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the alpha,beta unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of alpha,beta unsaturated arylsulfone.