VACCINE UNDERSTANDING PART OF THE CONSTANT REGION OF IGE FOR THE TREATMENT OF ALLERGIC REACTIONS INDUCED BY IGE.

摘要

THE INVENTION REFERS TO A VACCINE, PREFERENTLY FOR HUMAN BEINGS, AGAINST ALLERGIC REACTIONS MEDIATED BY IGE. THE VACCINE CONTAINS A PROTEIN THAT HAS ALL THE AMINO ACID SEQUENCE OF THE CONSTANT DOMAINS CH2-CH3 OF THE EPSILON CHAIN OF THE IGE MOLECULA OR A STRUCTURALLY STABLE UNIT OF SUCH AMINO ACID SEQUENCE, WHERE THE PROTEIN CAN BE OPENED ONLY MORE HETEROLOGY SUPPORT PROTEINS AND OPTIONALLY CONTAIN AN AUXILIARY. THE VACCINE IS INJECTED, WITH OR WITHOUT AUXILIARY, TO INCREASE THE CONCENTRATION OF ANTIBODIES ENDOGENOS AGAINST IGE IN THE PLASMA OF ALLERGIC SUBJECTS. IN PRACTICE, THE VACCINE CAN BE USED AGAINST ALL TYPES OF ALLERGIES USED BY IGE, BECAUSE ANTIBODIES DO NOT DEPEND ON THE SPECIFICITY OF THE IGE MOLECULUM ANTIGEN BUT REDUCES THE TOTAL RESERVE OF IGE OF THE SUBJECT. THEREFORE, THE VACCINE IS USEFUL FOR THE TREATMENT OF SUBJECTS THAT ARE DIFFERENT TYPES OF ALLERGIES MEDIATED BY THE IGE.The INCREASED CONCENTRATIONS OF ANTIBODIES AGAINST THE IGE REDUCE THE FREE RESERVE OF IGE SPECIFIES THE ANTIGEN, WHICH REDUCES THE GR A RELEASE MEASURED BY THE ALLERGY OF PHYSIOLOGICALLY VERY ACTIVE SUBSTANCES STORED OR PRODUCED TOGETHER WITH THE RELEASE OF GRANULES FROM THE MASTETIC CELLS AND BASOPHYL LEUKOCYTES.