IDENTIFICATION OF THE GENETIC DETERMINANTS OF THE EXPRESSION OF CYP3A5 POLYMORPH.

摘要

A polynucleotide selected from the group consisting of: (a) a polynucleotide that hybridizes under strict conditions with a CYP3A5 gene and that has the nucleic acid sequence of SEQ ID NO: 112; (b) a polynucleotide that hybridizes under strict conditions with a CYP3A5 gene and encodes a polypeptide having the amino acid sequence of SEQ ID NO: 141; and (c) a polynucleotide that hybridizes under strict conditions with a part of a CYP3A5 gene comprising SEQ ID NO: 111, wherein said polynucleotide has an additional nucleotide at the position corresponding to position 27131/27132 of the CYP3A5 gene as defined by the joined sequences of Access No.: AF280107.1, where position 166220 has been numbered +1 and position 174832 has been numbered +8613, and Access No.: AC005020.2, where position 27341 has been numbered +8614