RECOMBINANT POXVIRUS THAT UNDERSTANDS AT LEAST TWO ATI PROMOTERS OF THE VIRUELA DE LAS VACAS.

摘要

Recombinant poxvirus comprising at least two expression cassettes in the viral genome, each of which comprises the cow pox ATI promoter according to SEQ ID .: No. 1, a derivative thereof or a promoter sub-sequence ATI, and a coding sequence, wherein the expression of the coding sequence is regulated by said promoter, derivative or sub-sequence and wherein the derivative of the ATI promoter of cowpox is a sequence in which no more than 6 nucleotides are substituted, deleted and / or inserted in the sequence of SEQ ID .: No. 1, wherein the ATI promoter sequence has a length of at least 10 nucleotides of the sequence of SEQ ID .: No. 1 and where the promoter , derivative or the sub-sequence comprises nucleotides 22 to 29 of SEQ ID .: No. 1 and wherein the promoter, derivative or sub-sequence has the biological activity of being active as a promoter.