DUAL ANTAGONISTS OF NK1 / NK3 FOR TREATMENT OF SCHIZOPHRENIA.

摘要

The use of the compounds of the general formula wherein R 1 is aryl, unsubstituted or substituted by one or more substituents, selected from the group, consisting of alkyl, alkoxy, halogen, - (CH 2) or OH, -C (O) H, CF3, CN, S-alkyl, -S (O) 1,2-alkyl, -C (O) NR''R '' '', -NR''R '' '', -NR''C (O ) -alkyl, -NR''S (O) 2-alkyl, or is heteroaryl, selected from the groups, consisting of pyridin-2- or 3-yl, imidazolyl or oxazolyl, unsubstituted or substituted by alkyl, halogen or alkoxy ; R2 and R3 are independently of each other hydrogen, halogen, alkyl, alkoxy, OCHF2, OCH2F, OCF3 or CF3; R4, R5 are independently of each other hydrogen, - (CR''R '' '') 1- (CR''R '' '') 1- (CR''R '' '') 0, 1- OH or - (CR''R '' '') 1- (CR''R '' '') 1- (CR''R '' '') 0, 1-alkyl, where R '' and R '' '' in each carbon atom may be the same or different from each other, -C1, 2-alkyl, -C (O) H, - (CH2) or cycloalkyl, unsubstituted or substituted by hydroxyl, - (CH2 ) 1, 2, 3NR''R '' '', - (CH2) 1, 2, 3NR''C (O) -alkyl, - (CH2) 1, 2, 3NR''S (O) 2-alkyl , - (CH2) oS (O) -alkyl, - (CH2) oS-alkyl, - (CH2) or S (O) 2-alkyl; - (CH2) oS (O) 2-NR''R '' '' R '' is hydrogen, alkyl, - (CH2) oOH, -C (O) H, -C (O) -alkyl, -C ( O) -cycloalkyl, -S (O) 2-alkyl, -S (O) 2-halogen-alkyl, -S (O) -alkyl, -S-alkyl or -S (O) 2-N-di-alkyl , R '' '' is hydrogen or alkyl.