PROCEDURE FOR THE PREPARATION OF THE 11- (1-PIPERAZINIL) DIBENZO (B, F) (1,4) TIAZEPINA, AN INTERMEDIARY IN THE SYNTHESIS OF THE QUTIAPINE ANTIPSYCHOTIC MEDICINAL.

摘要

Process for the preparation of 11- (1-piperazinyl) dibenzo [b, f] [1,4] thiazepine or a pharmaceutically acceptable salt thereof, which comprises reacting the phenyl 2- (phenylthio) phenylcarbamate with piperazine and Cyclize the N - [(2-phenylthio) phenyl] -1-piperazinylcarboxamide obtained in the presence of a cyclising agent.