NEW ESTERES SELECTIVE INHIBITORS OF COX-2 DERIVATIVES OF INDOLALCANOLES AND NEW AMIDAS DERIVED OF INDOLALQUILAMINS.

摘要

Compound of the formula where R = C1 to C6 alkyl, C1 to C6 branched alkyl, C4 to C8 cycloalkyl, C1 to C6 hydroxyalkyl, C1 to C6 branched hydroxyalkyl, C4 to C8 hydroxy substituted aryl, C1 to C6 alkylamino primary, secondary or tertiary, alkylamino C1 to C6 branched primary, secondary or tertiary, C4 to C8 arylamino primary, secondary or tertiary, C1 to C6 alkylcarboxylic acid, branched C1 to C6 alkylcarboxylic acid, C1 to C6 alkyl ester, branched C1 to C6 alkyl ester, C4 to C8 aryl, acid C4 to C8 arylcarboxylic, C4 to C8 aryl ester, C1 to C6 alkyl substituted aryl-C4-C8 heterocycle, C4 to C8 alkyl or aryl heterocycle with O, N or S in the ring, C4 to C8 alkyl substituted alkyl or aryl heterocycle or aryl-substituted with O, N or S in the ring or halosubstituted versions of these, where halo is chlorine, bromine, fluorine or iodine; R1 = C1 to C6 alkyl, C1 to C6 branched alkyl, C4 to C8 cycloalkyl, C4 to C8 aryl, C1 to C6 alkyl substituted C4 to C8 aryl, C1 to C6 alkoxy, branched C1 to C6 alkoxy, C4 to C8 aryloxy or versions halo substitutes thereof or R1 is halo where halo is chlorine, bromine, fluorine or iodine; R2 = methyl; R3 = chlorobenzoyl, bromobenzoyl, iodobenzoyl, chlorobenzyl, bromobenzyl or iodobenzyl; n = 1, 2, 3 or 4; X = O or NH, and the compound possesses selectivity for the inhibition of cyclooxygenase-2 for use in medicine.