Phosphine compounds, complexes of transition metals with compounds contained as ligands therein containing such complexes and catalysts asymmetric synthesis.

摘要

A phosphine compound represented by the following formula (1): (see formula) wherein each of R 1 and R 2 independently represents a hydrogen atom, C1 a - 10, which may be substituted by hydroxyl groups C1 - 4 or halogen atoms; an alkoxy group C1 - 10, which may be substituted with alkyl C1 - 4 hydroxyl groups C1 - 4 or halogen atoms; an alkenyl group C2 - 10, which may be substituted with alkyl C1 - 4 alkoxy groups C1 - 4, phenyl, hydroxyl or halogen atoms; a di (C1 - 5) amino which may be substituted by hydroxyl, alkoxy groups C1 - 4 or halogen atoms; a cyclic amino group of 5 to 8 members which may be substituted with groups C1 - 4 or halogen atoms; an alicyclic group of 5 to 8 members which may be substituted with alkyl C1 - 4, hydroxyl groups C1 - 4 or halogen atoms; one, which may be substituted with aryl groups C1 - 4 hydroxyl groups C1 - 4 or halogen atoms; an aralkyl group which may be substituted with alkyl C1 - 4 hydroxyl groups C1 - 4 or halogen atoms; a heterocyclic group which may be substituted with alkyl C1 - 4 hydroxyl groups C1 - 4 or halogen atoms; trisubstituted silyl group selected from tri (C1 - 6) silyl groups, di (C1 - 6) (aryl C6 - C18) alkylsilyl, di (aryl C6 - C18) (C1 - 6) silyl, tri (aryl C6 - C18) alkylsilyl or tri (aralkyl C7 - 19) alkylsilyl or halogen atom; each of R 3, R 4, R 5 and R 6 independently represents a hydrogen atom, an alkyl group C1 - 5, an alkoxy group C1 - 5, a di (C1 - 5) amino, a cyclic amino group 5 to 8 members or a halogen atom; R 7 represents an alkyl group C1 - 5, a C1 - 5, a di (C1 - 5) amino, a cyclic amino group of 5 to 8 members or a halogen atom; and each of R 3 and R 4, R 5 and R 6, and R 6 and R 7 may be fused together to form a fused benzene ring, a fused, substituted benzene, a trimethylene group, a tetramethylene group, pentamethylene group, a methylenedioxy group, an ethylenedioxy group or trimethylenedioxy group.