FRANGIBLE COMPOUNDS FOR PATHOGEN INACTIVATION

摘要

The present invention is directed to compounds and methods for inactivatingpathogens in biological materials such as red blood cell preparations andplasma.Preferably, the compounds comprise a nucleic acid binding moiety, an effectormoietycapable of forming a covalent bond with the nucleic acid, and a frangiblelinkercovalently linking the nucleic acid moiety and the effector moiety. Hydrolysisof thefrangible linker upon incubation with the biological material occursconcurrently withthe reaction of the effector with nucleic acid but slow enough to permitinactivation ofpathogens in the biological material. The compounds and methods may be used totreat materials intended for in vitro or in vivo use such as clinical testingortransfusion. Exemplary compounds include the following general structuralformulas:(see formula I)and(see formula II)wherein the substituents are as defined herein.