(IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION

摘要

The invention comprises the use of compounds of formula (I) wherein the dottedline represents an optional bond; Xis oxygen or sulfur; R1 is hydrogen, C1-12alkyl, Ar1, Ar2C1-6alkyl,quinolinylC1-6alkyl, pyridylC1-6alkyl, hydroxyC1-6alkyl,C1-6alkyloxyC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, aminoC1-6alkyl,or a radical of formula -Alk1-C(=O)-R9, -Alk1-S(O)-R9or -Alk1-S(O)2-R9; R2, R3 and R16 each independently are hydrogen, hydroxy,halo, cyano, C1-6alkyl, C1-6alkyloxy,hydroxyC1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy, aminoC1-6alkyloxy, mono- ordi(C1-6alkyl)aminoC1-6alkyloxy, Ar1, Ar2C1-6alkyl, Ar2oxy,Ar2C1-6alkyloxy, hydroxycarbonyl, C1-6alkyloxycarbonyl, trihalomethyl,trihalomethoxy, C2-6alkenyl; R4 and R5 each independentlyare hydrogen, halo, Ar1, C1-6alkyl, hydroxyC1-6alkyl, C1-6alkyloxyC1-6alkyl,C1-6alkyoloxy, C1-6alkylthio, amino, hydroxycarbonyl,C1-6alkyloxycarbonyl, C1-6alkylS(O)C1-4alkyl or C1-6alkylS(O)2C1-6alkyl; R6and R7 each independently are hydrogen, halo, cyano,C1-6alkyl, 4,4-dimethyl-oxazolyl, C1-6alkyloxy or Ar2oxy; R8 is hydrogen, C1-6alkyl, cyano, hydroxycarbonyl, C1-6alkyloxycarbonyl,C1-6alkylcarbonylC1-6alkyl, cyanoC1-6alkyl, C1-6alkyloxycarbonylC1-6alkyl,carboxyC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl,mono-- or di(C1-6alkyl)aminoC1-6alkyl, imidazolyl, haloC1-6alkyl, C1-6alkyloxyC1-6alkyl, aminocarbonylC1-6alkyl, or a radical of formula-O-R10, -S-R10, -N-R11O12; R17 is hydrogen, halo, cyano, C1-6alkyl, C1-6alkyloxycarbonyl, Ar1; R18 is hydrogen, C1-6alkyl, C1-6alkyloxyor halo; R19 is hydrogen or C1-6alkyl; for the manufacture of a medicament toinhibit smooth muscle cell proliferation.