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EXCIPIENTS FOR USE IN ADENO-ASSOCIATED VIRUS PHARMACEUTICAL FORMULATIONS, AND PHARMACEUTICAL FORMULATIONS MADE THEREWITH
EXCIPIENTS FOR USE IN ADENO-ASSOCIATED VIRUS PHARMACEUTICAL FORMULATIONS, AND PHARMACEUTICAL FORMULATIONS MADE THEREWITH
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机译:用于与病毒相关的药物配制剂的赋形剂,以及由此制成的药物配制剂
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摘要
Stable pharmaceutical compositions comprising recombinant adeno-associatedvirus (AAV) virions are described. The compositionsprovide protection against loss of recombinant AAV vector genomes andtransduceability under conditions such as exposure to cycles offreezing and thawing and storage in glass or polypropylene vials. Thecompositions comprise recombinant AAV virions in combinationwith one or more dihydric or polyhydric alcohols, and, optionally, adetergent, such as a sorbitan ester. Also described are methods ofusing the compositions.
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