CARBAMATE AND THIOCARBAMATE PODOPHYLLOTOXIN DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention relates to novel compounds of formula (I): embedded image in which: R 1 represents a group chosen from hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arlylalkylsulfonyl, and phosphonic acid, R2 represents an oxygen atom or a sulfur atom, R3 represents a hydrogen atom, an alkyl, cycloalkyl or arylalkyl group, X represents a linear or branched (C1-C6) alkylene group, R4 represents a group chosen from amino optionally substituted with one or two groups, group of formula -N (R3) -X1-OR5 in which R3, X1 and R5 are as defined in the description, group of formula -N (R3 In which R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, group of formula -O-X1-OR5 in which R5 and X1 are such that ue defined in the description, and a group of formula -O-X1-NR6R7 in which R 6, R 7 and X 1 are as defined in the description, their isomers as well as their addition salts with an acid or a pharmaceutically acceptable base acceptable. The invention also relates to the pharmaceutical compositions containing them and to the process for their preparation.