ANGIOPOIETIN-LIKE 2 AS A BIOMARKER OF VASCULAR ENDOTHELIAL CELL ABNORMAL FUNCTION AND SENESCENCE

摘要

A method for assessing a physiological state of a mammal.The method includes: obtaining from the mammal a biological sample;measuring the expression of angiopoietin-like 2 in the biological sample; andassessing the physiological state of the mammal by comparing the measuredexpression of the angiopoietin-like 2 to a predetermined normal expressionlevel in normal subjects, wherein an increase in angiopoietin-like 2 leveloverthe predetermined normal expression level indicates an abnormal physiologicalstate.