NONALCOHOLIC STEATOHEPATITIS MODEL ANIMAL AND FATTY LIVER MODEL ANIMAL

摘要

A nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human liver cells into a nonhuman animal having immunodeficient hepatopathy to thereby construct a chimeric nonhuman animal, and then transplanting the human liver cells that have been proliferated in the body of this chimeric nonhuman animal into a nonhuman animal having immunodeficient hepatopathy of the same species as the nonhuman animal having immunodeficient hepatopathy as described above; a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human liver cells into a nonhuman animal having immunodeficient hepatopathy to thereby construct a chimeric nonhuman animal.