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Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same

机译:新型3-芳基-2,5-二羟基-1,4-苯醌衍生物,其制备方法和含有该衍生物的药物组合物

摘要

Compound of formula (I): wherein: RSUB1 /SUBand RSUB2/SUB, which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: RSUB4 /SUBrepresents hydrogen or alkyl, RSUB5 /SUBrepresents hydrogen, alkyl, aryl or heteroaryl, RSUB3 /SUBrepresents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-RSUB3 /SUBrepresents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.
机译:式(I)的化合物:其中:R 1 和R 2 ,它们可以相同或不同,各自代表氢,酰基或烷基,Ar代表芳基或杂芳基, A代表选自以下的基团:R 4 代表氢或烷基,R 5 代表氢,烷基,芳基或杂芳基,R 3 代表芳基,杂芳基,二环丙基甲基或二苯甲基,或AR 3 表示一个可选取代的萘基,但不包括2,5-二羟基-3-(4-甲氧基苯基)-6-(2-苯基乙烯基)- 1,4-苯醌,2,5-二羟基-3-(4-甲氧基苯基)-6-(2-萘基)-1,4-苯醌和2,5-二羟基-3-(2-萘基)-6-苯基-1,4-苯醌。包含其的药物产品可用于治疗与血糖失调有关的疾病。

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