METHODS TO INCREASE REVERSE CHOLESTEROL TRANSPORT IN THE RETINAL PIGMENT EPITHELIUM (RPE) AND BRUCH'S MEMBRANE (BM)

摘要

The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions that increase reverse cholesterol transport are utilized as therapeutic targets for age-related macular degeneration. In a specific embodiment, the lipid content of the retinal pigment epithelium, and/or Bruch's membrane is reduced by delivering Apolipoprotein A1, particularly a mimetic peptide.