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DIRECT REVERSAL OF THE SUPPRESSIVE FUNCTION OF CD4+ REGULATORY T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING
DIRECT REVERSAL OF THE SUPPRESSIVE FUNCTION OF CD4+ REGULATORY T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING
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机译:通过类似Toll样受体的信号直接逆转CD4 +调节性T细胞的抑制功能
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摘要
CD4SUP+/SUP regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .
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