Compounds, compostions, kits and methods of use to orally and topically treat acne and other skin conditions by adminstering a 19-nor containing vitamin D analog with or without a reyinoid

摘要

Topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 19-nor-26,27-dimethylene-20(S)-2-methylene-1±,25-dihydroxyvitamin D3, 2-methylene-1±,25-dihydroxy-(17E)-17(20)-dehydro-19-nor vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1±,25-dihydroxyvitamin D3, 2-methylene-23,23-difluoro-1±-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1±-hydroxy-19-nor-bishomopregnancalciferol, (2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1±-hydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof.