A disposable, multi-purpose cardiovascular autonomic neuropathy testing device comprising a tubular body, at least one ECG electrode disposed on the exterior of the tubular body for monitoring ECG signals of a patient holding the tubular body, a breathing sensor attached to the tubular body for momtopng breathing, a closure mechanism attached to the tubular body for selectively restricting the passageway wherein the first configuration is unrestricted and the second configuration restricted, and a pressure monitor attached to the tubular body for confirming a pre-determined pressure within the tubular body, whereby (i) when the closure mechanism is in a first configuration, the device can be used to conduct metronomic breathing tests, (??) when the closure mechanism is in a second configuration, the device can be used to conduct Valsalva maneuver tests, and (in) when the closure mechanism is in either configuration, the device can be used to conduct HRV standing tests.
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