METHOD TO IDENTIFY CD40-SENSITIVE CELLS USING GENE EXPRESSION

摘要

A method of differentiating between first diffuse large cell B lymphoma (DLCBL) cells and second DLCBL cells, known to respond to CD40 mediated apoptosis, based on differences in expression of one or more genes or a profile of genes and a method to differentiate between CD40 sensitive and CD40 resistant DLCBL cells based on the differences in gene expression of recombination activating gene 1(RAG 1), pre-B lymphocyte gene 1 (VPREB 1), lymphocyte specific protein tyrosine kinase (LCK) and VAV 1 oncogene (VAV 1).