MUTATIONS AND POLYMORPHISMS OF FMS-RELATED TYROSINE KINASE 1

摘要

This invention relates generally to the analytical testing of tissue samples in vitro, and more particularly to aspects of genetic polymorphisms and mutations of the FLTl gene. The invention provides new FLTl mutations and SNPs, useful in the diagnosis and treatment of subjects in need thereof. Accordingly, the various aspects of the present invention relate to polynucleotides encoding the FLTl mutations of the invention, expression vectors encoding the FLTl mutant polypeptides of the invention and organisms that express the FLTl mutant and polymorphic polynucleotides and/or FLTl mutant/polymorphic polypeptides of the invention. The various aspects of the present invention further relate to.diagnostic/theranostic methods and kits that use the FLTl mutations and polymorphisms of the invention to identify individuals predisposed to disease or to classify individuals with regard to drug responsiveness, side effects, or optimal drug dose.