THREE-DIMENSIONAL STRUCTURE OF HDHD4 COMPLEXED WITH MAGNESIUM AND A PHOSPHATE MIMETIC

摘要

The present invention relates to a three-dimensional crystalline form of a HDHD4, which was solved to provide a three-dimensional structure of a HDHD4. In one aspect of the present invention, HDHD4 is complexed with magnesium and a phosphate mimetic, such as vanadate. Methods of using the crystalline form, such as screening methods and rational modulator design methods, are also aspects of the present invention and are described. The structures of the present invention also provide insight into observed properties of HDHD4 and other polypeptides.